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As a result, even patients below the typical BMI threshold for GLP-1 as a weight loss treatment may still benefit from the same active ingredient

The median duration on the second GLP-1RA therapy before switching to a third therapy was highest for tirzepatide (5%) at 10.3 months, followed by dulaglutide (32.5%) at 9.4, semaglutide (28%) at 6, liraglutide (32.5%) at 5.6, and exenatide (2%) at 2 months

Based on clinical trial data, retatrutide produces greater average weight loss (28.7% at 68 weeks with 12mg) compared to tirzepatide (22.5% at 72 weeks with 15mg)

& Sacks, S

The timing amplifies the muscle-preservation effect of the training session