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By fusing GLP-1 with fatty acids for acylation, the molecular self-association is promoted, thus prolonging the diffusion time of the drug from the injection site
Weikel 2013
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Using 2mL gives you 2.5mg/mL concentration (20 IU = 0.5mg), while 2.5mL gives 2mg/mL (25 IU = 0.5mg)
At doses of 1 mg or less (the typical usage range), side effect rates were similar to placebo
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