This is based on the interaction of GSK-3 (and more precisely, its beta isoform, GSK-3) with many of the cellular components related to the neuropathology of AD, such as the amyloid precursor protein, the A peptide, the metabolic pathway leading to acetylcholine synthesis, which are mutated in many cases of familial AD
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Metal fragments in supplements typically arise from processing equipment, as manufacturing often involves heavy mechanical processing
A peptide is a short chain of amino acidsessentially a fragment of a protein