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Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy

Proc Natl Acad Sci USA 72 : 43764380

This finding has implications for functional GI disorders, though it remains preclinical 10

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An increased ratio of 3-hydroxykyurenine (3-HK) to kynurenic acid was observed in the plasma of PD patients, especially in those with L-DOPA-induced dyskinesia, indicating a predominance of neurotoxic over neuroprotective metabolites