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Semaglutide may be slightly better tolerated in people with pre-existing gastrointestinal disorders, as tirzepatide tends to cause more nausea and diarrhea
Heart rate The Phase 2 trial showed a dose-related increase in resting heart rate
[1] [3] These approvals were based on robust clinical trial programs demonstrating efficacy and acceptable safety profiles in these specific populations
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Semaglutide causes fatigue at similar rates to other GLP-1 medications like tirzepatide or liraglutide (10% to 15% of users)
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