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Both N-Terminal and C-Terminal histidine residues of the prion protein are essential for copper coordination and neuroprotective self-regulation
Produced in GMP-aligned (Good Manufacturing Practice) facilities
It is used to treat short stature in adults also
One difference between their model and the one reported here is that deletion of Gclc is induced in hepatocytes of adult mice (which are slowly proliferating), compared to theirs, where deletion of Gclc occurred in hepatocytes of growing animals (which are rapidly proliferating)
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