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Health Canada described the generic versions of semaglutide as complex synthetic products that are pharmaceutically equivalent to the brand name biologic drug, noting its review ensures that differences between these products do not affect the safety, efficacy, or quality of the drug
Limit test studies failed to establish an LD50, indicating exceptionally low acute toxicity even at very high doses
In the brain, semaglutide acts on areas that regulate appetite and food intake, particularly the hypothalamus and reward centres, leading to reduced hunger, increased feelings of fullness, and potentially decreased food cravings
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