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They aim to establish the dose-response relationship of a drug, a critical factor in defining its therapeutic window

2018;90(15):e1283e1290

Strengths of the current study include the large sample size, the detailed clinical assessment of depression and related characteristics, and the availability of the same data collected from participants still involved after 6 years of follow-up (totaling over 4,000 observations), which allowed further testing of the consistency of the detected associations

A cross-over study vs placebo Drugs Exp Clin Res 1987

Consideration of potential drug interactions and whether discussions have occurred with a primary care provider