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At the receptor level, MK-677 binds the growth hormone secretagogue receptor 1a (GHS-R1a) on somatotroph cells of the anterior pituitary and on hypothalamic neurons, mimicking the orexigenic peptide ghrelin
Goldenberg RM, Berard LD, Cheng AY, Gilbert JD, Verma S, Woo VC, et al
Elevated glucose levels impair tubuloglomerular feedback and promote afferent arteriolar vasodilation, resulting in glomerular hyperfiltration (47)
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