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Starting Dose and Titration Schedule Retatrutide phase 2 used a structured titration: Weeks 1 to 4: 2 mg subcutaneous once weekly Weeks 5 to 8: 4 mg once weekly Weeks 9 to 12: 8 mg once weekly Week 13 onward: 12 mg once weekly (maximum dose) Gastrointestinal adverse events drove dose reductions in 15.7% of participants receiving 12 mg in the phase 2 trial

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