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Drug after drug, trial after trial, the data consistently showed that these medicines did more than lower HbA1c: they appeared to protect the heart

Eli Lilly has stated it plans to do so this year for orforglipron as an obesity treatment, and in 2026 for treating patients with diabetes

Nourbakhsh, B

The Importance of Physician-Supervised Dosing Without medical oversight, there is no reliable way to assess whether a dose is working, whether its safe to increase, or whether underlying health factors need to be considered

Note that negative BMI change numbers represent BMI loss, and therefore a negative correlation implies increased drug efficacy with increased nausea