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When hydroxocobalamin is given in high doses (such as during cyanide poisoning treatment), unique effects can be observed: patients often experience a transient reddening of the skin or mucous membranes and a reddish discoloration of the urine due to drug excretion

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used in pregnancy (LMWH preferred), cancer-associated thrombosis (LMWH preferred per CLOT/SELECT-D trials), and with certain drug interactions Duration: 3 months minimum for provoked DVT (reversible risk factor)