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This concept is powerfully substantiated by a comprehensive meta-analysis encompassing seven major CVOTs, which concluded that the elevated risk of DR progression associated with semaglutide was driven by the magnitude and rapidity of HbA1c reduction, rather than a direct drug effect [86]

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Returning to the definition of half-life as the time required for the blood level to drop by half, if the steady state blood level of a drug with linear pharmacokinetics is considered to be 100%, then, if the drug is suddenly withdrawn, its level will drop to 50% after the first half-life, to 25% after the second half-life, to 12.5% after the third half-life, to 6.25% after the fourth half-life, and to 3.125% after the fifth half-life (Figure 1)

Glucagon-Like Peptide-1, a natural hormone that regulates insulin and appetite

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