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Semaglutide: While still highly effective, semaglutide typically results in weight loss of around 15% of body weight after two years

Lavalle-Cobo A, Masson W, Lobo M, Masson G, Molinero G (2021) Glucagon-like peptide-1 receptor agonists and cardioprotective benefit in patients with type 2 diabetes without baseline metformin: a systematic review and update meta-analysis

It argues they address different defects, with pioglitazone targeting insulin resistance at the tissue level and GLP-1 agonists targeting pancreatic beta cell function and satiety

I felt like I was owning up to a dirty, shameful secret as they drew their own conclusions