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Runge, S., Thogersen, H., Madsen, K., Lau, J
PMID: 2753890
2 GLP-1 receptor agonists, also known as GLP-1 analogs, are medications that help manage blood sugar levels in people with type 2 diabetes
Importantly, B 12 supplementation generally relieved the upregulation of these genes, in support of the idea that limiting B 12 levels were driving the Met restriction in vivo
Published clinical trial data generally shows higher average weight loss with brand-name tirzepatide than with brand-name semaglutide in controlled conditions - approximately 20.9% body weight reduction with tirzepatide in the SURMOUNT-1 trial versus approximately 14.9% with semaglutide in the STEP-1 trial
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