However, in contrast to rhEPO that has shown side effects in clinical trials, to date ARA 290 has been shown to be safe when formally evaluated in preclinical animal toxicology, normal human volunteers and patients with sarcoidosis (1921)
This is one of the practical differences from BPC-157 where proximity to the affected tissue does influence the local concentration
Furthermore, the functional relevance of endogenous neurogenesis is unclear due to the reduced survival of newborn cells in the striatum ( In addition to the striatum, several studies have found evidence that the cortex may also be capable of regeneration under certain conditions (Magavi et al., 2000), including after ischemia, albeit with a low number of newly formed neurons (Kaplan, 1981)
Starting at 500 mcg twice daily, injected subcutaneously in the deltoid region (avoiding the surgical incision area), provides robust regenerative signaling
Together, they provide a synergistic effect that promotes skin health, hydration, and rejuvenation