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Collectively, the diagram indicates that A45 exposure elicits pathway-level reprogramming that converges on oxidative stress and inflammation, with enrichment of processes often linked to fibrotic remodeling (e.g., amino-acid/collagen-related and energy-demanding pathways), supporting a plausible connection between A45 exposure and fibrosis-related biology
Toll-like receptors as a therapeutic target in the era of immunotherapies
In addition, there is a particular effect on endothelial integrity (indicated as +2)
Plasma levels of vitamin E and carotenoids are decreased in patients with nonalcoholic Steatohepatitis (NASH)
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