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Retention of glucagon function is required to achieve such an advantage over GLP-1 monotherapy

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"For somebody who is in the lower end of the weight spectrum, people who are more likely to be seen by primary care physicians, they would be more likely to use the orals," Aronne said

This is particularly concerning given that people with obesity-related comorbidities may reap the greatest benefit from treatment, said Professor Thomsen

Citation33 Actinobacteriota-derived acetate also may enhance insulin sensitivity via G protein-coupled receptor (GPCR) signaling in adipose tissue and the liver

Koopmann A, et al