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This may lead to subsequent physiological abnormalities including gut dysbiosis and systemic inflammation, eventually resulting in a pathological clotting system, chronic endothelialitis, vasoconstriction, and hypoxia, as found in similar conditions such as heat stroke (183)

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The biggest factors include: Peptide structure Half-life Dosage Injection frequency Kidney and liver function Metabolism Body composition Whether the peptide is short-acting or long-acting Certain peptides are designed with structural changes that slow how quickly the body clears them