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Methods: We combined screening data from 8 NAFLD/NASH non-cirrhotic phase 2 trials
While results are generally more modest than the higher-dose 2.4mg formulation, clinical studies and real-world experience show that patients can still expect steady improvements in weight and overall health
Particular caution is needed for patients with heart failure with reduced ejection fraction (HFrEF)
The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1
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