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Considering these changes in T2DM and the critical role of GLP-1 in glucose homeostasis, strategies for managing T2DM based on this hormone include addressing the differentiation of L-cells, increasing the endogenous production and secretion of GLP-1 through stimulants, extending the half-life of GLP-1 by inhibiting its degrading enzyme and targeting GLP-1R using its agonists

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