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Compared to continuous KD, every-other-day ketogenic diet (EODKD) induced a greater degree of ketosis but was associated with a tendency to suppress osteoclast activity and hinder early osteogenic differentiation of BMSCs, as indicated by TRAP and ALP staining, along with alizarin red assays
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There are additional concerns about stomach paralysis and malnutrition because of extreme appetite suppression
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