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13,407 Integrative analysis using scRNA-seq, ST, and spatial proteomics in melanoma identified the enrichment of mesenchymal-like (MES-like) cancer cells in ICI-nonresponsive lesions
Recent studies on Long COVID and ME/CFS patients have revealed signs of elevated oxidative stress and aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase, and lipid oxidative damage
These stimuli drive the accumulation of pro-apoptotic B-cell lymphoma 2 (Bcl-2) proteins on the outer mitochondrial membrane (OMM), thereby enhancing OMM permeabilization (102, 103)
