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doi: 10.4103/1735-3327.166169
A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Downs syndrome
Folic acid should be administered concomitantly if needed
The condition develops gradually, often over months or years, and is particularly common among older adults in the UK
In adults, however, a delayed period may sometimes be related to lifestyle factors, stress, contraception, pregnancy, or an underlying health condition
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