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This guide is the part the timeline doesn't coverthe three effects where male physiology changes the answer: what happens to muscle, to testosterone, and to erections
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Excessive alcohol consumption can increase the risk of cataract
Persistent vomiting/inability to tolerate oral fluids or nutrition can lead to dehydration
In Phase 3 studies: Participants without diabetes taking orforglipron lost approximately 9% to 10% of body weight over roughly 36 to 40 weeks Participants with type 2 diabetes generally lost around 7% to 8% By comparison, Wegovy's landmark STEP trials reported approximately 14.9% average weight loss over 68 weeks
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