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Geller, L

[78] found that Lira inhibited proprotein convertase subtilisin/kexin type 9 (PCSK9) expression in HepG2 cells and db/db mice through hepatocyte nuclear factor 1 (HNF1)-dependent mechanism, and may inhibit LDLR expression in db/db mice through PCSK9 independent pathway, and ultimately reduce liver cholesterol accumulation

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Healthcare providers should emphasize evidence-based interventions aligned with current clinical guidelines from organizations such as the American Diabetes Association, American Association of Clinical Endocrinology, and American Gastroenterological Association

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