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As Drucker pointed out to me: We know that GLP-1 is not getting directly to those neurons, but it's activating pathways that turn on those neurons
Ofori J, Tortoe C, Agbenorhevi JK
Nauck, M.A
It stimulates the growth of blood vessels and nerves, increases the synthesis of collagen, elastin and glycosaminoglycans, and supports the function of dermal fibroblasts
Studies by Greenwood-Van Meerveld and colleagues using rodent POI models demonstrated that ipamorelin produced dose-dependent improvements in gastric emptying and reversal of POI-induced delayed gastrointestinal transit, with effects mediated through GHS-R1a expressed in gastrointestinal smooth muscle and enteric nervous system tissue
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