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But theyre quick to point out that their work alone cannot show a cause-and-effect relationship between semaglutide and NAION, especially since its based on retrospective, observational data
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What is worth to summarize here is the fact that several pro-apoptotic stimuli induce an early extrusion of GSH from cells leading to a widespread mitochondrial damage and to cytochrome c release into the cytosol, the starting condition for apoptotic intrinsic pathway commitment
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