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Cost, administration route, side effects, drug-drug interactions (hormone therapy), and personal and family history may affect choice of agent
fatigue/tiredness appears in the broader tolerability profile but was not the dominant safety signal compared with GI events
The No DAC version is specifically used in laboratory models to observe the natural pulsatile release of hormones without the extended half-life provided by the Drug Affinity Complex
A supplemental video illustrates how a cell with apparent contact at low magnification, upon super-resolution reconstruction and 3D rotation, did not truly contact nearby axons (Supplementary video 1)
4 The LEGACY study tracked what happens when this is reversed
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