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In the STEP 1 trial, adults taking semaglutide 2.4mg alongside lifestyle changes lost an average of 14.9% of their body weight after 68 weeks, compared with 2.4% in the placebo group who received lifestyle advice alone
This matters because much of the public buzz around these medicines is about weight loss, while many early launches may be positioned first through the diabetes route
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However, its off-label use as a weight loss drug has raised concerns about potential side effects, leading to legal actions against its manufacturers
PMID: 39996356
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