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49 In another phase 1 study conducted in 37 Japanese patients, the most common treatment-related side effects were nausea, vomiting, abdominal discomfort, diarrhea, and headache, mostly mild to moderate in severity
Understanding what to expect during these transitions helps separate expected reactions from concerning ones
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Molecules involved in synaptic organization, such as cell adhesion proteins CADM2, regulate communication between enteric glia and neurons, and their disruption may contribute to dysfunctional ENS circuits and visceral pain in IBS 112
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