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Most studies have found a decrease in GLP-1 secretion in obese individuals [92], and some studies have found no difference in GLP-1 levels between obese and normal-weight controls [93]
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USA 114 , E5266E5275 (2017)
While data are insufficient, these signals raise alarms about potential influence on reproductive development in prepubescent and pubescent adolescents
Clinical trials for Zepbound showed that participants achieved an average weight loss of 15% to 22.5%, depending on dosage, with results tracked over 72 weeks under controlled conditions
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