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It reduces appetite, slows gastric emptying, and enhances glucose-dependent insulin secretion while reducing glucagon secretion

October 2023 : A study of 16 million patients (2006-2020) found that those who used GLP-1 agonists for weight loss were at a higher risk of pancreatitis, bowel obstruction, and gastroparesis compared to those who took bupropion-naltrexone instead

It is a structurally modified 39-amino-acid peptide engineered for once-weekly subcutaneous delivery in clinical trials

Eur J Clin Microbiol Infect Dis 33:16531659 Van Hoof E, Cluydts R, De Meirleir K (2003) Atypical depression as a secondary symptom in chronic fatigue syndrome

It is 8-10 times smaller than semaglutide and tirzepatide