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These mechanisms do not act independently but form an integrated regulatory network, with SIRT1 positioned centrally within the metabolismimmuneorgan axis. In processes including energy sensing, transcriptional control, redox balance, and cell fate determination, SIRT1 consistently occupies a central or upstream role in signal coordination, capable of orchestrating multiple pathways

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Given that many patients taking semaglutide have cardiovascular risk factors or established disease, this becomes a relevant consideration in treatment planning

Psychiatric and psychological adverse effects associated with dulaglutide, semaglutide, and liraglutide: a VigiBase study

Respiratory Research , 24 (1), 187