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Across various studies, treatments such as GA, curcumin, resveratrol, sesamol, and others consistently demonstrated beneficial microbial shifts, including elevations in protective taxa like Bacteroidetes , Bifidobacterium , Lactobacillus , Rikenellaceae , Alloprevotella , and phyla such as Proteobacteria and Actinobacteria , alongside reductions in detrimental groups like Helicobacter , Bacteroidaceae , Rikenella , and Prevotella [20, 22,23,24,25, 27, 28, 31, 33, 34, 38]

Additionally, they play a critical role in the metabolism of fats into glucose, which is fundamental for the function of aerobic cells to generate energy (, )

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Given that pulmonary NTM disease has been reported to be a multifactorial condition ( Although the present findings underscore the importance of the Nrf2-SLPI axis, some limitations should be noted