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Matsumura A, Kubota T, Taiyoh H, Fujiwara H, Okamoto K, Ichikawa D, et al
This variation reflects the different amounts of melanin present and the time required to influence established pigmentation patterns
The data are not publicly available due to privacy or ethical restrictions
In acute iron exposure, Nrf2 may protect from iron-induced injury, whereas long-term iron exposure resulted in iron accumulation, cytosolic ROS formation, and increased HO-1 (HMOX-1) mRNA expression, and this was accompanied by nuclear translocation of Nrf2 and induction of its target protein NQO1 (van Raaij et al., 2018)
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