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Both semaglutide and tirzepatide have long half-lives
It also demonstrated efficacy against antibiotic-resistant strains by promoting autophagy, potentially contributing to M.tb clearance and reducing the risk of drug-resistant diseases [68]
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This matters for managing side effects, planning surgeries (GLP-1 agonists can cause aspiration risk under anesthesia due to delayed gastric emptying), and understanding the timeline for return of appetite after stopping weight-loss medications
Both approaches are reasonable given current evidence
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