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5 mg vial = 5,000 mcg total 2 mL water = 2,500 mcg per mL 2,500 mcg target = 1.0 mL draw TB-500 10 mg vial with 3 mL example A 10 mg TB-500 vial mixed with 3 mL gives about 3,333 mcg/mL, or 3.33 mg/mL
Some companies, including Lilly, are also exploring oral GLP-1 receptor agonists, which DIMarchi refers to as small molecule mimetrics. These molecules, however, are far more complex than traditional oral small molecules
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Manzanares W et al (2010) High-dose selenium for critically ill patients with systemic inflammation: pharmacokinetics and pharmacodynamics of selenious acid: a pilot study
Even though there have been no studies evaluating this approach, its something we definitely see in clinical practice. Who should consider microdosing GLP-1s
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