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Tirzepatide-specific notes: Because it's a dual agonist with stronger effects on appetite, some people experience slightly more gastrointestinal side effects initially, particularly nausea
Currently, no established scientific evidence demonstrates that semaglutide directly causes infertility in men or women
Ipamorelin also influences gastrointestinal motility through GHSR-1a receptors
A 2025 study in older adults with diabetes found GLP-1 receptor agonist exposure was associated with higher incident neovascular AMD risk
They saw ~4 kg weight loss in the active group, but the standout finding was microbiome shifts: big increases in anti-inflammatory genera like Faecalibacterium (+154%) and Alistipes (+153%), and a drop in Lactobacillus (77%)
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