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doi: 10.1146/annurev-psych-010814-015249 89 Programme CEGOBaiY.DiH.et al

Pickart estimated the toxic dose at approximately 22,500 mg, which is over 11,000 times the recommended daily dose

A shortage of B12 results in the accumulation of methylmalonyl-CoA, which can cause the neurological issues associated with vitamin B12 deficiency

This means it has not undergone FDA review for safety, efficacy, or manufacturing quality , and it cannot be marketed or sold legally as a dietary supplement or medication for human consumption

Rodent trials showed 50% faster ligament recovery, with users at 500 mcg/day noting reduced joint pain and stronger lifts after 46 weeks, aiding long-term performance