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N-acetylcysteine (NAC) is the best option to avoid constipation while supporting glutathione levels it shows less than 5% constipation incidence at standard doses (6001800mg daily) because it converts to glutathione inside cells after absorption, avoiding direct gut lumen exposure
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If you have risk factors or these symptoms, your doctor may recommend testing for vitamin B12 deficiency
Proc Natl Acad Sci U S A 110:48044809
