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GIP receptor activation Glucose-dependent insulinotropic polypeptide (GIP) is the second receptor target, similar to tirzepatide (Mounjaro, Zepbound): Effects: Enhances insulin release from the pancreas Works synergistically with GLP-1 for appetite control May influence fat storage and energy balance Improves glucose regulation Tirzepatide's success as a dual GLP-1/GIP agonist demonstrated that adding GIP to GLP-1 enhances weight loss beyond GLP-1 alone
Common effects are gastrointestinal, while serious reported events include pancreatitis, acute kidney injury, and hypersensitivity reactions
10.1093/ecam/nel094 71 Tovar-y-RomoL
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prior bariatric or weight-loss surgery
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