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They also offer optional premium coaching ($49.99/mo) with nutrition guidance and lifestyle planning, making Shed one of the few providers that bridges the gap between medication-only and full-service programs

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In eye diseases like DR, high blood glucose and oxidative stress activate the Notch1-Hes signaling pathway, leading to ECM imbalance and promoting vascular dysfunction, inflammation, and retinal damage (Fan et al., 2020)

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Due to the huge difference in single excretion cycles, the full course span of the two drugs is entirely different

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Conflict of interest The authors declare the following conflicts of interest: MS-R has received honoraria for presentations from HRA Pharma

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