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Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates
For optimal synergy, combine collagen with vitamin C and light mechanical loading (movement or rehab work) to stimulate collagen crosslinking
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Why the Combination Matters The three-receptor activity creates what researchers describe as a complementary pharmacological triangle: GLP-1 reduces intake, GIP enhances the metabolic benefits of incretin signaling, and glucagon increases energy output
Pennone V, Angelini E, Sarlah D, Lovati AB
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