The most clearly defined groups who may be considered in future include individuals with: Metabolic dysfunction-associated steatotic liver disease (MASLD) particularly those with concurrent obesity, type 2 diabetes, or metabolic syndrome Metabolic dysfunction-associated steatohepatitis (MASH) the progressive inflammatory subtype associated with fibrosis and risk of cirrhosis Obesity with elevated liver enzymes (ALT/AST) where hepatic steatosis has been confirmed on imaging Type 2 diabetes with evidence of hepatic fat accumulation , where current glucose-lowering therapies have not adequately addressed liver disease Patients with significant hepatic fibrosis (stage F2 or above) represent a group with particularly high unmet need, as there are currently no licensed pharmacological treatments specifically approved for MASH in the UK

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Mito-morphosis: mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function
Clinical trials on Ozempic demonstrate reductions of 7.9 % to 17.3 % in body weight, decreases in HbA1c levels, and reductions in waist circumference and blood pressure
Intravenous administration would overcome these problems, as it allows instant circulation of the precursors rather than initial metabolism by the gut microbiota and liver