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The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice
Once damaged, cartilage often struggles to heal properly without intervention
They are designed to interact with the body's melanocortin system, a sprawling network of signaling pathways that governs a surprising number of physiological processes
doi: 10.18632/oncotarget.10418 217 PardoMGarcia.AntrobusRBlancoMJDwekRAZitzmannN
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