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Micronutrients in HIV-positive persons receiving highly active antiretroviral therapy

235 A notable positive feedback loop amplifies TGF- signaling: TGF--induced Smad2/3 activation upregulates TGFBRAP1, which competitively binds TRI and prevents its degradation by Smurf1/2-mediated ubiquitination

Parenthetically, the Vroman effect describes the dynamic and competitive adsorption of plasma proteins onto material surfaces when they come into contact with biological fluids

The most compelling candidates address multiple mechanisms simultaneously, which is why they show stronger results than compounds targeting a single pathway