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Activated leukocytes express adhesion molecules that help them interact with the vascular wall, making this a crucial step in developing vascular dysfunction, cell migration, and inflammatory perpetuation of cerebral damage [28]

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For many patients, symptoms improve with continued therapy as the body adapts, though individual experiences vary

Vomiting also increased with dose escalation, occurring in up to one in four patients on the highest dose, compared with 4.8% in the placebo group

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