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Different microelements like selenium and zinc have no antioxidant action themselves but are required for the activity of many antioxidant enzymes

For instance, female mice administered BSO exhibited much higher susceptibility to acetaminophen-induced hepatotoxicity than male mice [43], while male mice treated with BSO were much more susceptible to thiabendazole nephrotoxicity than females [44]

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When extended therapy is unlikely to help, she may be able to avoid additional exposure to bone toxicity and its impact on long-term bone health.

While it is possible that metabolite levels were affected by antipsychotic medication, our sample is comprised of the least-treated subjects of all MRS glutamate and GSH studies in schizophrenia reported to date (median treatment duration = 2.27 DDD-days)