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Other contributing factors include medication interactions (certain psychiatric medications, corticosteroids, and reduced exposure to oral contraceptives during dose escalation), hormonal changes (thyroid dysfunction, menopause), inadequate sleep (less than 7 hours nightly), chronic stress with elevated cortisol, and reduced physical activity as patients become more comfortable at their current weight
It modulates various signaling pathways, including those involving Nuclear Factor-kappa B (NF-B), a protein complex that plays a significant role in controlling DNA transcription and cell survival
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pubmed.ncbi.nlm.nih.gov/37366315 Jastreboff AM, et al
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